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Here, we report that the combination therapy of As 2 O 3 with L-buthionine-sulfoximine (BSO), which inhibits a critical step in glutathione synthesis, effectively enhanced in vitro growth inhibition effect of As 2 O 3 on all 11 investigated cell lines arising from prostate, breast, lung, colon, cervix, bladder, and kidney cancers, compared with As 2 O 3 treatment alone

The positively selected CSCs by chemotherapy showed altered lipid metabolism signatures, resulting in accumulation of lactate, which acidifies ascites, leading to T cell dysfunction and Treg polarization ( Due to the heterogeneous nature of ovarian cancer, responses of treatment targeting different tumor driving molecules vary among individuals

NF-B is liberated due to IB degradation and then enters the nucleus to activate the transcription of inflammatory molecules

Helaas kunnen de niveaus van deze antioxidant uitgeput raken door vele factoren, zoals veroudering, een slecht dieet en een zittende levensstijl

Automatic Detection of White Matter Hyperintensities in Healthy Aging and Pathology Using Magnetic Resonance Imaging: A Review