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Though the concept of a healthy microbiota is challenging to define, dysbiosis can usually be defined as a certain imbalance where the pathogenic species are dominant over beneficial symbionts and commensals (Hou et al
Phenotypic divergence in vegetable amaranth for total antioxidant capacity, antioxidant profile, dietary fiber, nutritional and agronomic traits
Neurochem Res 47:517530 Matsuda Y, Ozawa N, Shinozaki T, Wakabayashi KI, Suzuki K, Kawano Y, Ohtsu I, Tatebayashi Y (2020) Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances

Specifically, hypermethylation of CpG sites at gene promoters affects specific tumor suppressor genes such as SLIT2, PTEN, OPCML, RASSF1A, p16, MLH1, E-calmodulin and APC (58)

Clinically manifested as progressive visual field defects and optic nerve damage, the selective and irreversible loss of retinal ganglion cells (RGCs), the central input neurons of the retina, forms the basis of glaucomatous pathology [320]
