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Male rats aged 15, 20, and 24 months received intraperitoneal ethanol (1.5 g/kg/day) or saline for 13 weeks, followed by a 2-month withdrawal period

Oxidative damage reduces osteoblastic synthesis and functioning, leading to bone remodeling dysfunction

Zahran, E., Elbahnaswy, S., Mamdouh, A

Given that the cellular cystine/cysteine/GSH/Gpx4 axis is an important pathway to protect cells from undergoing ferroptosis ( - ) by increasing the level of glutamate or an exogenous stimulant, such as sulfasalazine, can deplete intracellular GSH, reduce Gpx4 substrate availability and disrupt the axis (53)