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therefore studies on men and women over the age of 50 yr demonstrated no differences for homocysteine levels between healthy women and men (269)

therefore, it is considered that the main function of MRPs is the transport into the bile duct, not into the blood stream, and that glutathione is required only by this transporter family as a co-transporter of other substrates for MRP (for instance, estrogens and sulfates) [113,114]

It is important mentioning that some of these results (attenuation of muscle damage and oxidative stress parameters) were obtained from animal studies, thus, it is not possible to guarantee that the same effects would occur in human trials

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