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TNF-, IL-1 and IL-6 are associated with activation of bone-resorbing processes, and IL-8 is reported to polymorphonuclear leukocyte activity.[5,34] More recently, Dias et al .,[99] first time revealed that significant redox disturbances exist in neutrophils of patients with periodontitis, which are associated with deregulation of anti-inflammatory transcription factor Nrf2 pathway resulting in neutrophil hyperactivity/hyper-reactivity

One critical point in understanding at the molecular level the toxicity of thiol-binding mineral elements such as As, Cd, Hg and Pb is that in ex vivo , in vitro assays toxicity occurs at micromolar concentration

Given these associations, GSH warrants further research as a novel therapeutic and risk-assessment biomarker

10.1016/S0140-6736(96)07493-4

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