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This is because the carboxylate groups of these acyl-CoA molecules can undergo endogenous nucleophilic attack on the thioester bond of coenzyme A, resulting in the formation of a cyclic anhydride that is more reactive than the parent acyl-CoA, thereby facilitating a more effective non-enzymatic modification of proteins

Plant Cell Physiol 33:541553 Mller IM, Jensen PE, Hansson A (2007) Oxidative modifications to cellular components in plants

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The DNA of Caenorhabditis elegans

doi: 10.1007/s10787-021-00889-6 174 CherbuinNWalshEILeachLBruestleABurnsRAnsteyKJet al