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The concentration of EV was measured via a BCA assay kit (Beyotime, China)

Acknowledgements The authors are thankful to the Nursing team and supporting staff at the Bangalore Medical College and Research Institute and to the volunteers for their participation in the study

The titration schedule is a maximum framework, not a mandatory escalation

Endothelial cell dysfunction DAMPs significantly increase the transcription and release of pro-inflammatory factors in endothelial cells by activating TLRs and the NF-B signaling pathways, thereby triggering chronic inflammation and vascular injury

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