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The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation

Blood 127:1214 Xie Y, Kang R, Klionsky DJ, Tang D (2023) GPX4 in cell death, autophagy, and disease

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Abbreviations RCD: Regulated cell death SLC7 A11: Solute Carrier Family 7 Member 11 PPP: Pentose phosphate pathway GSH: Glutathione NCKAP1: Nck-associated protein 1 WRC: WAVE regulatory complex PDI: Protein disulfide isomerase 2ME: 2-Mercaptoethanol ENO2: Enolase 2 T3: Triiodothyronine THRSP: Thyroid Hormone Responsive Spot 14 ALL: Acute lymphoblastic leukemia GSK-3: Glycogen synthase kinase 3 GLUTs: Glucose transporter proteins LDHA: Lactate dehydrogenase A HK: Hexokinase 2-DG: (2-Deoxy-D-glucose) GOx: Catalyzed by glucose oxidase G-6-P: Glucose 6-phosphate 2-HG: 2-Hydroxyglutarate NOX4: NADPH oxidase 4 DEN: Diethylnitrosamine TGF-: Transforming growth faction- ER: Endoplasmic reticulum IDO1: Indoleamine 2,3-dioxygenase 1 MDSCS: Myeloid-derived suppressor cells TME: Tumor microenvironment CAFs: Cancer-associated fibroblasts SOCS2: Suppressor of cytokine signaling 2 HCC: Hepatocellular carcinoma TNBC: Breast cancer ICIs: Immune checkpoint inhibitors GTPase: Guanosine triphosphatase GPX: Glutathione peroxidase TrxR: Thioredoxin reductase TCA: Tricarboxylic acid Cu: Copper 4-OI: 4-Octyl itaconate NOXs: NADPH oxidase ES: Elesclomol DSF: Disulfiram TTM: Tetrathiomolybdate PDHA1 KO: Pyruvate dehydrogenase E1 knockout GLS1: Glutaminase 1 GLUD1: Glutamate dehydrogenase 1 IDH2: Isocitrate dehydrogenase 2 CcRCC: Clear cell renal cell carcinoma References Peng F, Liao M, Qin R, Zhu S, Peng C, Fu L, et al