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FIGURE 2 Ketone bodies are increasingly recognized as important energy substrates for the heart, with a better balance between the quantity and efficiency of energy production (Lopaschuk, 2017

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PhinneySDBistrianBREvansWJGervinoEBlackburnGL.The human metabolic response to chronic ketosis without caloric restriction: Preservation of submaximal exercise capability with reduced carbohydrate oxidation

A choline analogue, 3,3-dimethylbutanol (DMB), has been uncovered with inhibitory effect to choline TMA lyase activity in turn decreasing circulating TMAO, and therefore attenuating the promoting role of choline in atherosclerosis (Wang et al., 2015)

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