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The resultant increase in portal pressure may cause development of APSC as well as ascites
290 Mechanistically, IL-1 amplifies the inflammatory cascade by activating MAPKs and NF-B, thereby promoting further cytokine and chemokine release
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[20] However, consideration for the use of an alternative topical agent (e.g., azelaic acid, benzoyl peroxide, clindamycin, erythromycin) may be appropriate for some patients
