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While these can contribute, they may not be the sole explanation

[5] A trial conducted in 2004 on 300 obese patients by a Melbourne-based biotechnology company, states that they recorded successful weight loss over the course of 12 weeks

Conflict of interest The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

This means you would either need a larger syringe or split your dose into two injections

Its the simplest, most accessible thing we do and for the right patient, its also one of the most genuinely felt