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Hyperoxia showed neither increase in O(2) uptake nor decrease in lactate release, irrespective of increased O(2) supply, venous Po(2) and vascular resistance, as compared to normoxia, suggesting that hyperoxia decreases O(2) diffusion conductance and/or effective O(2) supply probably due to arteriovenous O(2) diffusion shunt

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Stocca G, Vicini S

Single Cell Omics Symposium abstract 2020

No Western regulatory-standard trials, and no FDA approval
