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SAM, another substrate of NNMT, not only provides methyl groups for histone and DNA methylation but also provides propylamine groups for polyamine biosynthesis
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Treatment with cyanocobalamin or hydroxocobalamin may unmask this condition
Another interesting compound, quercetin, has been shown to inhibit the activity of CD38 by binding to its active site, which results in increased intracellular NAD + 143
