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10.1161/01.CIR.89.3.1203 102 SimonneauG.RubinL

The formation of protein disulfide bonds serves as an indicator of oxidative stress linked to neurodegeneration (Landino et al., 2014)

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[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%
