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In all, these results provide evidence of the remarkable efficacy of 1D228 in suppressing tumor growth without causing any discernible toxicity, surpassing the effectiveness of the current drug Tepotinib

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156 The intimate association between the apical cytoskeleton and intestinal epithelial tight junctions has long been investigated

These results are consistent with previous reports 49 , UVB irradiation induced increased expression of pro-apoptotic proteins Bax and caspase-3 in concert with the repression of antiapoptotic proteins Bcl-2, while accompanied by collagen loss and an increase of MMPs
