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The manufacturer received a Complete Response Letter in 2015 indicating the application could not be approved in its current form

Gonadorelin/GnRH stimulates the release of two key hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary gland

On one hand, most studies remain in the stages of compound isolation, identification, and in vitro activity screening, verifying their protective effects on lung epithelial cells, macrophages, etc., through cell experiments or extracellular enzyme experiments, while in-depth in vivo studies are relatively scarce