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In CuCP complex, which constitutes approximately 75% from the total copper pool (our data and 4,5 ), the copper ions are bound in protein interior, which makes them kinetically inert and practically nonexchangeable at physiological pH values even in the presence of high millimolar concentrations of powerful Cu(II)-chelating ligands like EDTA or DTPA

As muscle and nerve tissue have very high energy requirements, defective mitochondrial energy production may lead to an energy shortage during stress that affects nerve function, especially the autonomic nerves that control the gut

However, the specific mechanism of the FGF5 gene in the development of hair follicles is unclear, and whether it has other effects besides promoting changes in the follicular cycle is currently elusive

CSD subregions also inhibit vascular hyperpermeability in mice with angiotensin II-induced myocardial fibrosis 10

The workflow described in this study maps the identified metabolites to specific metabolic pathways, which can then be traced to the corresponding genes and species harbouring the genes, thereby facilitating the elucidation of functional contributions by the microbiota to the complex metabolite profile of the gut