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Deficiencies in glutamate uptake and the glutamate-glutamine cycle can lead to problems in neuronal signaling and promotes excitotoxicity (reviewed by Danbolt, 2001

29 In a Morris water maze test, rats were administered either a mixture of A 140 (intracerebroventricular infusion) and ()-huperzine A (1) (0.1 or 0.2 mg/kg, IP, once per day for 12 consecutive days), A 140 (intracerebroventricular infusion) alone, or a vehicle control

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