glutathione transferases and neurodegenerative diseases The Role of Metabolism in Chronic Illness Development Its Potential Use as a Novel Therapeutic Target Glutathione transferases and neurodegenerative diseases

Intention of the article is the collection of data to support the view that Wilson disease is a complex multifaceted and unique copper overload condition, where intracellular accumulation of toxic free copper, but not total copper, causes organ damage

[18] [19] Their detoxification involves both broad-spectrum and specialized enzymatic systems, including families that act on reactive carbonyls and other electrophiles, as well as dedicated pathways for particularly toxic intermediates

Dev Cell 22(4):707720

Thus, the BCL-2 inhibitor venetoclax and the MCL-1 inhibitor AZD-5991 have potent targets for CLL treatment

Clinical Lipidology, a companion to Braunwalds Heart Disease