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Fluorescent staining was visualized and images were acquired with a 63x oil immersion objective (NA = 1.2) with a 2x optical zoom on a Leica Stellaris 5 White Light Laser Confocal Microscope coupled to a camera integrated with LasX software for Lightning deconvolution (Leica Biosystems, Deer Park, IL, USA)
Early exploration of this type of linker was successfully conducted by Genentech/ImmunoGen, such as in the ADC drug trastuzumab emtansine (T-DM1 or Kadcyla) for treating HER2-positive metastatic breast cancer
Increased levels of ROS during exercise modify specific cysteine residues on the Keap1 protein, which normally binds to Nrf2 and facilitates its degradation
Schulte-Hermann, R., and Parzefall, W
Extracellular superoxide dismutase (ECSOD): Marklund described EC-SOD in 1982 [24]
