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10.1016/s1095-6433(01)00422-6 113 FinnertyF

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Graphical abstract Keywords: Polyphenols, Apoptosis, Neuronal loss, Beta amyloid, Cognitive dysfunction, Learning and memory impairment, Parkinsonism Introduction Neurodegenerative diseases are a heterogeneous group of chronic, usually age-related disorders that are characterized by the progressive loss of neurons, deformation of the neuron structure, or loss of neuron function [1]

Cell-autonomous metabolic deregulation of cancer cells, or metabolic adaptation to microenvironmental cues (lack of nutrients, stromal supply, hypoxia, etc.), represent the triggering event of mitochondria overexploitation to orchestrate nutrient sensing and upload, signaling, and redox circuits