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Grade III includes anaplastic astrocytomas

Basra J Vet Res 19(3) Liu H, Hou C, Zeng Q, Zhao L, Cui Y, Yu L, Wang L, Zhao Y, Nie J, Zhang B, Wang A (2016) Role of endoplasmic reticulum stress-induced apoptosis in rat thyroid toxicity caused by excess fluoride and/or iodide

The increase of free iron leads to Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH + OH ), resulting in ROS accumulation and non-enzymatic lipid peroxidation, which leads to the imbalance of antioxidant system and membrane integrity defect, and finally leads to ferroptosis (Forcina and Dixon 2019) (Fig

Analogous with the majority of the previously reported oxidase-like nanozymes, pFeSAN as oxidase mimetics with oxygen as electron acceptor might generate reactive oxygen species (ROS, e.g.OH, 1 O 2 ,O 2 ) to oxidize TMB 1,2,3

The supply of amino acids might come from protein recycling or being compensated by downregulation of the synthesis of other polymers such as flagellum assembly, but this supply seems to be insufficient, according to our results