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Three specific gaps separate this preclinical evidence from a human recommendation, and it is worth naming each so the framing throughout this guide is not mistaken for false modesty

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If you stop suddenly: You might notice rebound dullness or breakouts (especially if skin was already sensitive) Oxidative stress can spike temporarily, especially if theres no antioxidant support from diet or skincare If you taper: Your body has a chance to adjust its GSH homeostasis more gently You can monitor changes and compensate with diet, skincare, or other supplements A lot of U.S.-based functional medicine docs recommend a cycling approach on for 3 months, off for 1

It is also suitable if you are medically stable and willing to follow a supervised treatment plan

Otherwise, the clinical characteristics of the groups were similar