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Description
3.3.3 Sacituzumab tirumotecan, sac-TMT Sac-TMT is an innovative ADC targeting TROP-2, which incorporates 2-methylsulfonylpyrimidine as the linker, attached to a topoisomerase I inhibitor (62)
Cells that maintain and repair the liver identified
AC5KO mice are found to be resistant to cardiac stress with an enhanced median life span of roughly 30%, with protection from bone demineralization, and decreased susceptibility to fractures or aging-induced cardiomyopathy (Yan et al., 2007)
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