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12,13 The criteria included the following: Apoptosis or necrosis Degeneration of hepatocytes Hepatic sinusoids, central vein (dilatation or congestion) Inflammatory cells Parenchyma architecture Scoring was as follows: = No changes watched

Four isomers of the NAChemin adduct and five isomers of the GSHhemin adduct were detected to elute significantly earlier than hemin, delineating the hydrophobicity of hemin to be compromised

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