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The enhanced phagocytic and oxidative burst activities observed in our study reflect the essential roles of selenium, copper, and zinc as cofactors for key enzymes involved in neutrophil and macrophage bactericidal functions ( In the present study, the phagocytic activity of both milk neutrophils and macrophages peaked around parturition and was significantly enhanced in the combined supplemented group, followed by the multiminerals, multivitamins, and control groups

Interestingly, the commentary surrounding the equivocal nature of the evidence in this area has not included any reference to the predominant use of elderly participants in these studies, or whether providing an absolute maximum of three B vitamins (folate, B 6 , B 12 ), simply on the basis that these will reduce levels of homocysteine, is a rational approach, given the inextricably inter-linked functions of all eight B vitamins (and the potential for deficiencies/insufficiencies in any of these vitamins)