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PQS production starts during early stationary phase and is maximal during late stationary phase

This multi-layered regulation ensures that when pyruvate is directed into gluconeogenesis, glycolytic flux is simultaneously reduced, and vice versa, allowing for metabolic coordination in response to the cells energy status and systemic hormonal cues

Joseph, L

TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells

ii) positive regulation, driven by ferritinophagy overactivation, degradation of antioxidant proteins and regulators such as USP13, to promote ferroptosis