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Worldwide data show a decline in sperm concentration (0.64 million/mL per year) from 1973 to 2011 (5)
& Choi, J.-W
doi: 10.1016/j.patbio.2009.09.014 6
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Shklar and coworkers (173) examined the effects of methotrexate on hamster buccal pouch carcinomas generated by 9,10-dimethyl-l,2-benzanthracene and found that the methotrexate-treated group reported tumors that were larger and more anaplastic and that they progressed more quickly than the control group
