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Trials should also incorporate sex-specific analyses, age related stratification, and clinically relevant comorbidities such as gastrointestinal dysfunction and sleep problems, all of which can modulate treatment efficacy

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Symptoms of toxicity and GHB poisoning include: Slowed heartbeat (bradycardia) Slowed respiration, which may decrease to fewer than 15-20 breaths/minute Tremors Seizures Lowered body temperature Loss of consciousness Coma Fatalities are generally associated with respiratory depression and asphyxiation