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Adaptation pathways (brainstem nausea circuit, sinus-node baroreflex) respond to rate of change in receptor occupancy

doi: 10.1038/sj.ejcn.1600911

It, in turn, requires LC as a cofactor

Further education improves cognitive reserve and triggers improvement in selective cognitive functions in older adults: The Tasmanian Healthy Brain Project

Skipping days or using it sporadically could reduce its effectiveness
