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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Orefice L.L., Waterhouse E.G., Partridge J.G., Lalchandani R.R., Vicini S., Xu B

56 However, more direct assessments of intracellular oxidant stress through measurement of GSSG formation showed no evidence of oxidant stress during the metabolism phase in rats, 64 mice, 65 or mouse hepatocytes

However, whether these findings translate into a potential therapeutic target by modulating hepatic homocysteine levels remains to be determined in prospective, interventional studies