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La efectividad puede ser menor sin una adecuada dieta y rutina de ejercicio, lo que limita su uso como solucin nica

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[19] Fragile X syndrome: A 2015 Cochrane review of ALCAR in fragile X syndrome found only two placebo-controlled trials, each of low quality, and concluded that ALCAR is unlikely to improve intellectual functioning or hyperactive behavior in children with this condition