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Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment

58,59 demonstrated that downregulation of IFN-sensitive gene expression by interference with STAT-1 methylation can promote interaction with the protein inhibitor of activated STATs (PIAS)

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Although most UGA-containing transcripts do not facilitate Sec incorporation, transfer of a 3 UTR with a SECIS element to heterologous gene transcripts with a UGA codon embedded in an open reading frame is sufficient to direct Sec incorporation (217, 219, 322)

Initial results demonstrated that several N- and C-terminal modifications lead to dramatically improved stability while maintaining the capability to reverse scopolamine-induced deficits in Morris water maze performance and augment hippocampal synaptogenesis