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Perform a skin patch test prior to use

At endoscopy, the colorectal mucosa has dark brown-black discoloration that may be diffuse or patterened (see image 1)

This condition can stem from issues in the testes, ovaries, pituitary gland, or hypothalamus, leading to symptoms like fatigue, low libido, infertility, and mood changes

J Am Acad Dermatol 50:554562 Weinstock MA (1994) Malignant melanoma of the vulva and vagina in the United States: patterns of incidence and population-based estimates of survival