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The DNA methylation patterns in PGR, FOXO1 (Forkhead Box O1) and inflammatory cytokines including IL-1, TNF- impact CL dysfunction leading to adverse pregnancy outcomes (196)
Emerging research links this to anxiety, depression, and even schizophrenia, where dysbiosis correlates with reduced short-chain fatty acids (SCFAs) like butyrate, which normally calm neural inflammation
Lee JY, Nam M, Son HY, Hyun K, Jang SY, Kim JW, et al
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Although neutrophil activation is vital for host defense, excessive activation leads to tissue damage by cytotoxic and immune cell-activating agents, such as proteinases, cytokines, and ROS [36]
