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Furthermore, oxidative stress can impede the nucleoplasmic translocation of pancreaticoduodenal homeobox factor 1 (PDX-1), impair energy metabolism, and reduce insulin production and release (Duni et al., 2019)

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140,141 TBK1 mediates the activation of nuclear factor-B (NF-B) and interferon (IFN) regulatory factor 3 (IRF3)

Pathologically activated astrocytes exhibit disrupted intracellular signaling or metabolic homeostasis, impairing EAAT2 transcription, translation, or trafficking