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& Kozyrskyj, A

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This dualistic outcome likely stems from the distinct physiological roles of lactate and associated acidosis: elevated lactate itself may not impair muscle function and might even support performance, yet the concomitant severe intracellular acidosis (pH 6.56.2), especially in fast-twitch fibers, reduces calcium sensitivity and impairs myosin ATPase activity, ultimately inducing muscle fatigue

Y., Krishnan, S., Randolph, T

DSIP has been evaluated in experimental frameworks examining stress-induced changes in neuroendocrine signaling