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The Centers for Medicare & Medicaid Services reports that $4.9 trillion is spent annually on healthcare expenses in the U.S., yet populations continue to experience rising rates of chronic illness, obesity, and medication dependency, prompting the shift toward preventative longevity medicine

The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)

10.1016/j.neuron.2008.10.010 Neuron 156 McCoyM