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doi: 10.1152/ajpcell.00139.2004 56 Vander HeidenMGCantleyLCThompsonCB

TB-500s biological activity is mediated primarily through binding of the LKKTETQ actin-binding motif to G-actin and sequestering actin monomers, regulating actin polymerisation dynamics, and activating downstream signalling through the PI3K/Akt pathway that promotes cell survival, migration, and proliferation in multiple cell types relevant to tissue repair including endothelial cells, fibroblasts, keratinocytes, and myocytes

1 Additional risk factors for recurrence of disease include 30 or more days of zoster-associated pain during acute infection, ocular hypertension, and uveitis following acute infection

it manages the entire process like a thermostat