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Simulations suggest that glutathione pools are most sensitive to exposure duration at pharmacologically and supra-pharmacologically relevant doxorubicin concentrations

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HPLCMS analysis after solubilization with acidified methanol confirmed an almost stoichiometric conversion of 3,4- cis -leucocyanidin ( 6 ) into cyanidin ( 8 ), while the formation of the side products epidihydroquercetin ( 9 ), and quercetin ( 11 ) was reduced (Extended Data Fig

[115] described that phosphoglycerate dehydrogenase (PHGDH), involved in the synthesis of serine and glycine from glucose, is critical for pancreatic tumor cells proliferation and tumorigenesis, mediating cell-tight junctions formation, mTOR activation (through Akt), and protein expression and translation, after interaction with the translation initiation factors eIF4A1 and eIF4E (which seems to be independent of its enzymatic activity)

Proc Natl Acad Sci USA 93(15):79237926