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Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions

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Investigations for hypothyroidism (thyroidstimulating hormone and/or T4/T3 serum levels), acute pancreatitis (serum lipase), Addison disease (serum cortisol and/or an adrenocorticotropin stimulation (ACTH) stimulation test), mitochondrial disease (serum lactate, pyruvate), or less common metabolic disorders such as acute intermittent porphyria (urine porphyrins) may be considered, especially with supporting symptoms

Optom Vis Sci 91:171177

Impurities can act as partial agonists, reduce receptor affinity, or introduce endotoxin-driven signaling that mimics or obscures IGF-1R biology
