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20 When incorporated into pentenoate-functionalized hyaluronic acid (HA) hydrogels alongside RGD, the conjugation of both SPPEPS and RGD significantly enhanced collagen II expression in rat BMSCs by approximately 300 folds compared with the control group

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Serum MMA of 100 to 750 nmol/L, urine MMA of 1 to 4 nmol/L, and serum homocysteine of 6 to 29 mol/L are the reference ranges for most methods.10 If the normalisation of elevated serum homocysteine and MMA levels in response to vitamin B 12 replacement therapy is used as a diagnosis of deficiency, up to 50% of patients may be missed when the diagnosis is based on low vitamin B 12 level (150 pmol/L) alone.18 19 Rise in homocysteine level before increase in MMA is an early indicator of vitamin B 12 deficiency