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Observations such as eosinophilic muscle fibers, disruption of intercalated discs, and severe mitochondrial degradation point to a progressive degenerative process that compromises cardiac tissue integrity

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The ideal therapeutic concentration of ketones is between 1 and 3 mmol/L, and SGLT2 inhibitors elevate ketone levels within this range ( 5.4.2 Other medications In addition to SGLT2 inhibitors, some drugs have also been observed to alter ketone levels in patients to varying degrees