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Interestingly, there is a poor correlation between RNA expression changes after T cell activation and the levels of encoded proteins, suggesting that regulation of much of the proteome in these cells occurs posttranscriptionally (37, 39)

The promoters of BNIP3 and NIX both include functional HIF-1-responsive elements (HREs) and are elevated by hypoxia, indicating their possible roles in hypoxia-induced apoptosis [142,143,144]

More and more research reveals that neurovascular disorders play an important role in the pathophysiology of brain diseases throughout life, such as neurodevelopmental and neurodegenerative disorders (Ouellette et al

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