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Future studies should integrate single-cell spatiotemporal omics, optogenetic modulation, and organoid models to systematically elucidate the hierarchical architecture of exercise-activated cardioprotective networks, thereby establishing theoretical foundations for personalized cardiac rehabilitation strategies

Indeed, in vitro and epidemiological studies have demonstrated elevating effects of glutamine on GLP-1 secretion in GLUTage cells more than other amino acids and even glucose [15, 41]

Gabet Y, Muller R, Regev E, Sela J, Shteyer A, Salisbury K, et al

In vitro and preclinical studies demonstrate that inhibiting key regulators (e.g., GPX4) effectively induces ferroptosis, reducing GBM cell viability and tumor growth [11]