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This study found the high BP group had increased plasma levels of I-FAPB, zonulin, and LPS [48]
This simultaneously triggers ICD, reprograms the immunosuppressive TME through PD-L1 upregulation and synergy with anti-PD-L1 therapy, enhancing antitumor efficacy [87]
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Similarly, the combination of an anti-TGF monoclonal antibody, PF-03446962, with regorafenib in CRC is also under investigation (194)
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase
