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In order to extrapolate animal data for risk assessment, each screening procedure should cover a sensible level of exposure and a comparable condition to that found in man
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Focusing on SIRT3, recent studies indicate that its activation is generally protective
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Foxo3a-dependent bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in kupffer cells
