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They consist of mitochondrial dysfunction affecting the cellular energy metabolism, calcium homeostasis in the heart affecting contractility of the myocardium, changes caused to the protein structure and function such as proteins in the extracellular matrix and contractile proteins, and post translational modifications that occur like O-GlcNAcylation and lysine - hydroxybutyrylation which are dysregulated in the diabetic heart (112)

Ma, Q.-X

Current studies show that treatment of cortical neurons with glutamate resulted in an increase in Bax with a decrease in Bcl-2 proteins, loss of the MMP followed by a release of cytochrome c, and activation of caspase-9, representing the classical mitochondrial apoptotic pathway ( Figure 3 )

doi: 10.1021/la2025846

10.1016/j.molcel.2016.11.003 21 BloomgardenZ