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The underlying reason for this higher stability at pH 5.5 is due to the establishment of stable, durable hydrogen bonds between residues V196, F197, and T319 and the O-atoms at the terminals of the substrate

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Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C: Threonine 180 is required for g-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in xenopus oocytes

The fermentation solution comprised of phenolic acids, methylxanthines, and flavonoids, which actively contributed to the inhibition of enzymatic activity associated with skin aging
