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Hawley SA, Gadalla AE, Olsen GS, Hardie DG

Cystic transmembrane conductance regulator (CFTR) expression is diminished in NSCLC

Among DNMTs, the de novo methyltransferases DNMT3A and DNMT3B establish methylation patterns on unmethylated DNA through embryonic development (Figure 1) (Smallwood et al., 2011)

A previous study reported that -KG, the metabolite of Glu, is more abundant in Th17 cells than in Treg cells, suggesting that glutaminolysis may be more active in Th17 cells (47).Further mechanistic findings revealed that 2-hydroxyglutarate (2-HG), a direct product of error-prone dehydrogenase activity on -KG, could trigger hypermethylation of the Foxp3 gene and inhibit Foxp3 transcription, thereby inhibiting the differentiation of Treg cells and regulating Th17/Treg homeostasis through epigenetic mechanisms ( Figure 2 ) (48)

Moreover, Treg cells can restrict CD4 + T cell overactivation and its dysfunction is involved in SLE pathogenesis (5961)